The abrogative effect of propolis on acrylamide-induced toxicity in male albino rats: Histological study

Abstract The present study investigated the toxic action of acrylamide (ACR) and abrogative effect aqueous propolis extract on ACR-induced toxicity in male albino rats. Forty adult rats were randomly divided into four groups administered treatment doses orally by gavage. Control, treated with a physiological solution (5.0 ml/rat). ACR-treated group, ACR 25 mg/kg. + propolis, mg/kg 100 propolis. Propolis-treated period was 28 days, using gavage stomach tube. results showed that presence increased ( P < 0.001) level liver enzymes alanine aminotransferase (167.2 vs 90.15) aspartate (120.66 41.52) tissue serum lipid peroxidation products (80.11 39.3); also, it decreased total capacity antioxidants (113.4 189.41) compared to control group. histological analysis kidney revealed alterations induced ACR, including atrophy, necrosis, renal glomeruli tubular enlargement glomeruli, hemorrhage, edema surrounding blood vessels. Also, improved functions because propolis’s efficiency against harmful effects ACR. Moreover, examination negative changes, focal necrosis hepatocytes. Microscopic within seminiferous tubules, sloughing, desquamation sperm cells lumen. an infiltration protein substances between tubules degenerative vacuolar changes observed. renal, hepatic, testicular tissues appeared almost similar except for some minor changes. This proved feeding reduced these pathological restored normal state. It is concluded significantly biochemical damage caused recommends as cytoprotective agent